Light emitting compounds are of the great interest in our society because of their multiple applications in different fields i.e. sensors, markers or OLED’s among others.Taking advantage of our research experience regarding the synthesis and photophysical properties of group 11 complexes, a deep study on different metal complexes considering their different oxidation state as well as geometry, the presence of metallic interactions, etc. could lead to improve considerable the light emissive devices nowaday avaliable. For this purpose, we will use a large variety of ligands and
metaloligands that we have designed for the preparation of compounds bearing
metalophillic interactions, different functionalized fluorophors such as
modified indole, fluorene, BODIPY, carborane, etc. and Au(III) complexes with
the proper ligands to avoid the deactivation caused by d-d transitions as well as
heterobimetallic complexes with d6 or lanthanide metals.
Aminoacids and peptides: Auranofin, a thiolate Au(I) derivative, presents antiartritic effect as well as of many others thiolated DNA bases derivatives, such as thiopurine and thioganine. In addition, aminoacids have a great importance when it comes to transport drugs within the tumoral cells because of the higher concentration of aminoacid receptors in those cells in comparison with those present in healthy cells. Consequently, the desing of gold thiolates bearing aminoacid or peptides seems and attractive manner to deepen in the development of novel antitumoral agents and drug transporters.
Thioureas: Thiourea derivatives are versatile ligands with a great affinity to coordinate different metals (Ni, Fe, Cu, Zn, Co, Cd, Pb), thus affording neutral, mono anionic or di-anionic species. Such coordinative ability is the key for their application as metal scavenger, which would be useful in many industrial processes to reduce environmental contamination. From a biological point of view, thioureas derivatives and their metal complexes are known to have bactericidal, fungicidal and herbicidal activity. Furthermore, the thioureas coordination affinity for essential metals allows the possibility of elucidating the role of those essential metals in biological systems.
Luminescent d6 transition metal complexes (Re(I), Ru(II) and Ir(III)) and lanthanide derivatives arise as exceptional competitors of traditional dyes in medicine. Apart from their excellent photophysical properties, which are crucial in medical diagnosis, their biological properties can be easely modified by conjugating different biomolecules, and thus, inducing specific localisation, or behavior among others features. Moreover, recent studies also demonstrate the antitumoral activity of these type of metallic species, as for instance in the case of Ru(II) species NAMI-A and KP1019, which encourage the further development of similar complexes in order to improve their bioactivity
We will carry out the synthesis of new compounds bearing ylide, carbene or allene ligands that could be efficient catalysts in order to promote different catalytic processes. The corresponding C-H activation and C-C and C-X bond formation reactions will be explored. In addition, urea, thiourea and selenourea derivatives will be used to prepare different metal-organocatalysts, in order to check whether the coordination of the metal centre enhances the yield and the enantioselectivity of the organocatalysts. The mechanism of action, the characterization of intermediate species and the possible improvement of the process will be addressed, through the convenient modification of the catalytic structure. The use of theoretical calculations will be an essential tool for such purpose.